Endothelial cell senescence and vascular dysfunction
10.20039/j.cnki.1007-3949.2024.10.013
- VernacularTitle:内皮细胞衰老与血管功能障碍
- Author:
Chen LIU
1
;
Jiao CHENG
;
Ye LIU
;
Hui SUN
;
Xing WEI
Author Information
1. 南华大学心血管疾病研究所动脉硬化学湖南省重点实验室
- Keywords:
senescence;
endothelial cell;
vascular dysfunction
- From:
Chinese Journal of Arteriosclerosis
2024;32(10):916-920
- CountryChina
- Language:Chinese
-
Abstract:
Endothelial cell senescence is increasingly recognized as an important factor in the development of vascu-lar dysfunction and age-related diseases.As is well known,the occurrence of endothelial cell senescence involves multiple factors,and endothelial cell senescence and vascular dysfunction interact with each other.This review summa-rized the phenotypic changes of endothelial cell senescence,and reviewed the relationship between endothelial cell senes-cence and various vascular dysfunction,such as dysfunction of vascular relaxation and contraction,impaired vascular barrier function,and vasculitis.The aim is to provide reference for delaying human vascular aging and improving vascular function.
