Osteogenic transition of vascular smooth muscle cells phenotype and vascular calcifi-cation
10.20039/j.cnki.1007-3949.2024.07.011
- VernacularTitle:血管平滑肌细胞表型的成骨转换与血管钙化
- Author:
Cheng CHEN
1
;
Zheng ZHANG
;
Yu PENG
;
Xiaowei NIU
Author Information
1. 兰州大学第一临床医学院,甘肃兰州市 730000
- Keywords:
atherosclerosis;
vascular calcification;
vascular smooth muscle cell;
osteogenic transition of vas-cular smooth muscle cell
- From:
Chinese Journal of Arteriosclerosis
2024;32(7):627-633
- CountryChina
- Language:Chinese
-
Abstract:
Vascular calcification refers to the process of calcium salt deposition in the blood vessel wall,leading to vascular stiffening and loss of elasticity.It commonly occurs in middle-aged and elderly individuals,especially those with chronic conditions such as atherosclerosis,hypertension,diabetes,and chronic kidney disease.Vascular calcification is an active process,and one of the key events is the transdifferentiation of smooth muscle cells into osteoblast-like cells.These cells release calcium ions during the calcification process,leading to calcium salt deposition and the formation of cal-cified plaques.Vascular calcification is regulated by various factors,including high levels of phosphate and calcium,oxi-dative stress,and mechanical stress.Traditional Chinese medicine research has shown potential in attenuating vascular calcification,with substances such as Ganoderma lucidum spore powder and its derivatives,Panax notoginseng,baicalin,geniposide,and triptolide.These studies provide important evidence for further understanding and intervention in vascular calcification and reveal potential inhibitory factors that could be explored for future treatments.
