Research advances in endoplasmic reticulum stress and cardiovascular disease
10.20039/j.cnki.1007-3949.2024.04.011
- VernacularTitle:内质网应激与心血管疾病的研究进展
- Author:
Liang LI
1
;
Mei ZHANG
;
Keming CHEN
Author Information
1. 兰州理工大学生命科学与工程学院;中国人民解放军联勤保障部队第九四○医院基础医学实验室,甘肃省兰州市 730050
- Keywords:
endoplasmic reticulum stress;
unfolded protein response;
cardiovascular disease
- From:
Chinese Journal of Arteriosclerosis
2024;32(4):355-363
- CountryChina
- Language:Chinese
-
Abstract:
Endoplasmic reticulum(ER)is the predominant membrane structure in eukaryotic cells and is a key or-ganelle for the occurrence of important intracellular physiological processes.Under the action of various internal and ex-ternal factors,the homeostasis of ER is disrupted to block protein processing and transport,and the accumulation of unfol-ded or misfolded proteins in the ER lumen,forms endoplasmic reticulum stress(ERS)and triggers the unfolded protein re-sponse(UPR).Moderate ERS reduces protein synthesis,promotes protein degradation,and increases molecular chaper-ones that assist protein folding through the UPR signaling pathway,ultimately relieving ER stress.However,if the ERS is too strong or prolonged and exceeds the cell's ability to regulate itself,the UPR can initiate apoptosis and lead to diseases.Numerous studies have shown that ERS is closely associated with the development of several cardiovascular diseases(CVD).This review focuses on the research progress of UPR in several common types of CVD and targets UPR as a po-tential therapeutic approach for CVD.
