Regulation of autophagy by posttranslational modification of TFEB
10.20039/j.cnki.1007-3949.2024.03.001
- VernacularTitle:TFEB的翻译后修饰对自噬的调节作用
- Author:
Yiming YANG
1
;
Jiayin CHAI
;
Wen WANG
Author Information
1. 首都医科大学基础医学院,北京市 100069
- Keywords:
transcription factor EB;
autophagy;
posttranslational modifications
- From:
Chinese Journal of Arteriosclerosis
2024;32(3):185-193
- CountryChina
- Language:Chinese
-
Abstract:
Transcription factor EB(TFEB)is a member of the microphthalmia associated transcription factor family.It plays an important role in lipid metabolism and other biological processes by regulating the expression of auto-phagy and lysosomal related genes.The activity and cellular localization of TFEB can be regulated by posttranslational modifications of proteins.This paper discusses the mechanism of autophagy regulation by TFEB posttranslational modifica-tion,aiming to help understand the pathogenesis of related diseases caused by abnormal autophagy,and provides new ideas and feasible intervention targets for the prevention and treatment of corresponding diseases.
