Prognostic factors in children with acute T-lymphoblastic leukemia:a single-center clinical study of the CCCG-ALL-2015 protocol
10.7499/j.issn.1008-8830.2402079
- VernacularTitle:儿童急性T淋巴细胞白血病预后影响因素分析——CCCG-ALL-2015方案单中心临床研究
- Author:
Wen-Feng FU
1
;
Yong-Jun FANG
Author Information
1. 南京医科大学附属儿童医院血液肿瘤科,江苏南京 210008
- Keywords:
Acute T-lymphoblastic leukemia;
Minimal residual disease;
Clinical characteristic;
Prognosis;
Risk factor;
Child
- From:
Chinese Journal of Contemporary Pediatrics
2024;26(10):1078-1085
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical characteristics of children with acute T-lymphoblastic leukemia(T-ALL)and analyze their relationship with prognosis.Methods A retrospective analysis was conducted on the clinical data and follow-up results of 50 children with T-ALL who were treated using the CCCG-ALL-2015 protocol at the Department of Hematology and Oncology,Children's Hospital of Nanjing Medical University from November 2015 to December 2019.Kaplan-Meier survival analysis and Cox regression analysis were employed to identify factors affecting prognosis.Results Among the 50 T-ALL patients,there were 7 cases of relapse.There was no statistically significant difference in the baseline clinical data between the relapse group and the non-relapse group(P>0.05).However,the positive rate of minimal residual disease(MRD)(≥0.01%)on day 46 after induction remission therapy in the relapse group was significantly higher than that in the non-relapse group(P=0.037).The 5-year overall survival rate for the 50 patients was(87±5)%,and the 5-year event-free survival rate was(86±5)%.Multivariate Cox regression analysis indicated that the MRD level on day 46 after induction remission therapy was an independent prognostic factor(HR=0.104,95%CI:0.015-0.740,P=0.024).Conclusions MRD is of significant importance for the prognosis of T-ALL children.Personalized treatment should be provided based on MRD levels to prevent relapse and improve prognosis in these patients.
