Recent research on gene polymorphisms and genetic susceptibility of neonatal sepsis
10.7499/j.issn.1008-8830.2401065
- VernacularTitle:基因多态性与新生儿败血症的遗传易感性研究进展
- Author:
Jing GAO
1
;
Jian-Bo SHU
;
Yang LIU
Author Information
1. 天津市儿童医院/天津大学儿童医院龙岩院区新生儿科,天津 300134;天津医科大学研究生院,天津 300070
- Keywords:
Sepsis;
Genetic susceptibility;
Gene polymorphism;
Single nucleotide polymorphism;
Neonate
- From:
Chinese Journal of Contemporary Pediatrics
2024;26(8):879-886
- CountryChina
- Language:Chinese
-
Abstract:
Neonatal sepsis is a common and severe infectious disease with a high mortality rate.Its pathogenesis is complex,lacks specific manifestations,and has a low positive culture rate,making early diagnosis and personalized treatment still a challenge for clinicians.Epidemiological studies on twins have shown that genetic factors are associated with neonatal sepsis.Gene polymorphisms are closely related to susceptibility,disease development,and prognosis.This article provides a review of gene polymorphisms related to neonatal sepsis,including interleukins,tumor necrosis factor,Toll-like receptors,NOD-like receptors,CD14,triggering receptor expressed on myeloid cells-1,mannose-binding lectin,and other immune proteins,aiming to promote precision medicine for this disease.
