Recent research on pyroptosis in sepsis-induced myocardial depression
10.7499/j.issn.1008-8830.2312039
- VernacularTitle:细胞焦亡在脓毒症心肌抑制中的作用研究进展
- Author:
Ri WEN
1
;
Tie-Ning ZHANG
;
Ni YANG
;
Chun-Feng LIU
Author Information
1. 中国医科大学附属盛京医院儿童急诊与重症医学科,辽宁沈阳 110004
- Keywords:
Sepsis;
Myocardial depression;
Pyroptosis
- From:
Chinese Journal of Contemporary Pediatrics
2024;26(7):774-781
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis-induced myocardial depression(SIMD),a common complication of sepsis,is one of the main causes of death in patients with sepsis.The pathogenesis of SIMD is complicated,and the process of SIMD remains incompletely understood,with no single or definitive mechanism fully elucidated.Notably,pyroptosis,as a pro-inflammatory programmed cell death,is characterized by Gasdermin-mediated formation of pores on the cell membrane,cell swelling,and cell rupture accompanied by the release of large amounts of inflammatory factors and other cellular contents.Mechanistically,pyroptosis is mainly divided into the canonical pathway mediated by caspase-1 and the non-canonical pathway mediated by caspase-4/5/11.Pyroptosis has been confirmed to participate in various inflammation-associated diseases.In recent years,more and more studies have shown that pyroptosis is also involved in the occurrence and development of SIMD.This article reviews the molecular mechanisms of pyroptosis and its research progress in SIMD,aiming to provide novel strategies and targets for the treatment of SIMD.
