Value of calprotectin S100 A8/A9 in predicting the severity of Mycoplasma pneumoniae pneumonia in children
10.7499/j.issn.1008-8830.2401076
- VernacularTitle:钙卫蛋白S100 A8/A9对肺炎支原体肺炎患儿病情严重程度的预测价值
- Author:
Pei ZHOU
1
;
Li PENG
;
Lu XU
;
Qing-Hua LIU
;
Han HUANG
;
Li-Li ZHONG
Author Information
1. 湖南师范大学附属第一医院/湖南省人民医院儿童医学中心儿童呼吸病学湖南省重点实验室,湖南长沙 410005
- Keywords:
Mycoplasma pneumoniae pneumonia;
Calprotectin S100 A8/A9;
C reactive protein;
Child
- From:
Chinese Journal of Contemporary Pediatrics
2024;26(7):716-722
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of calprotectin S100 A8/A9 complex in evaluating the condition of children with severe Mycoplasma pneumoniae pneumonia(SMPP).Methods A prospective study was conducted among 136 children with Mycoplasma pneumoniae pneumonia(MPP)and 30 healthy controls.According to the severity of the condition,the children with MPP were divided into mild subgroup(40 children)and SMPP subgroup(96 children).The levels of S100 A8/A9 complex and related inflammatory factors were compared between the MPP group and the healthy control group,as well as between the two subgroups of MPP.The role of S100 A8/A9 in assessing the severity of MPP was explored.Results The MPP group had a significantly higher level of S100 A8/A9 than the healthy control group,with a significantly greater increase in the SMPP subgroup(P<0.05).The multivariate logistic regression analysis showed that the increases in serum C reactive protein(CRP)and S100A8/A9 were closely associated with SMPP(P<0.05).The receiver operating characteristic(ROC)curve analysis showed that the combined measurement of serum S100 A8/A9 and CRP had an area under the ROC curve of 0.904 in predicting SMPP,which was significantly higher than the AUC of S100 A8/A9 or CRP alone(P<0.05),with a specificity of 0.718 and a sensitivity of 0.952.Conclusions S100 A8/A9 is closely associated with the severity of MPP,and the combination of S100 A8/A9 with CRP is more advantageous for assessing the severity of MPP in children.
