Clinical characteristics and labial gland pathological features in children with systemic lupus erythematosus complicated by Sj?gren's syndrome
10.7499/j.issn.1008-8830.2402073
- VernacularTitle:儿童系统性红斑狼疮合并干燥综合征的临床特点及唇腺病理特征分析
- Author:
Sang CHENG
1
;
Hai-Yan XUE
;
Lan-Fang CAO
Author Information
1. 上海交通大学医学院附属仁济医院儿科,上海 200001
- Keywords:
Sj?gren's syndrome;
Systemic lupus erythematosus;
Clinical characteristics;
Focus score;
Child
- From:
Chinese Journal of Contemporary Pediatrics
2024;26(7):695-700
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinical manifestations,laboratory features,and labial gland pathological features in children with systemic lupus erythematosus(SLE)complicated by Sj?gren's syndrome(SS).Methods A retrospective analysis was conducted on 102 children with SLE who underwent labial gland biopsies at Renji Hospital,Shanghai Jiao Tong University School of Medicine from January 2013 to December 2022.The children were divided into two groups based on the presence of SS:the SLE with SS group(SLE-SS;60 children)and the SLE-only group(42 children).According to the focus score(FS)of the labial glands,children in the SLE-SS group were further subdivided into FS≥4 subgroup(26 children)and FS<4 subgroup(34 children).The clinical data of the groups were compared.Results Compared to the SLE-only group,children in the SLE-SS group had less skin and mucosal involvement,were more likely to have positive anti-SSA and anti-SSB antibodies,and had higher levels of rheumatoid factor(P<0.05).There was no significant difference in treatment protocols between the two groups(P>0.05).Compared to the FS<4 subgroup,the FS≥4 subgroup had more frequent musculoskeletal involvement(P<0.05),but there was no significant difference in SLE disease activity or other major organ involvement between the subgroups(P>0.05).Conclusions Children with SLE complicated by SS are less likely to have skin and mucous membrane involvement and exhibit specific serological characteristics.The SLE-SS children with an FS≥4 are more likely to experience musculoskeletal involvement.However,FS is not associated with disease activity or other significant organ damage.
