Value of different endoscopic scoring methods in assessing disease activity in pediatric Crohn's disease
10.7499/j.issn.1008-8830.2311103
- VernacularTitle:不同内镜评分法评估儿童克罗恩病疾病活动度的价值
- Author:
Wen DENG
1
;
Zhong-Yue LI
;
Bo LIU
Author Information
1. 重庆医科大学附属儿童医院消化科/国家儿童健康与疾病临床医学研究中心/儿童发育疾病研究教育部重点实验室/儿童发育重大疾病国家国际科技合作基地/儿科学重庆市重点实验室,重庆 400014
- Keywords:
Crohn's disease;
Endoscopic score;
Crohn's disease activity;
Child
- From:
Chinese Journal of Contemporary Pediatrics
2024;26(6):584-591
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the value of different endoscopic scoring methods in assessing disease activity in pediatric Crohn's disease(CD).Methods A total of 70 children diagnosed with CD at the Children's Hospital of Chongqing Medical University from January 2018 to January 2023 were included.Clinical disease activity was assessed using the Pediatric Crohn's Disease Activity Index(PCDAI),while different endoscopic scores were assigned based on endoscopic findings.Spearman rank correlation analysis was used to evaluate the correlation between each endoscopic scoring method and PCDAI as well as laboratory indicators.Kappa test was used to assess the consistency between colonoscopy/capsule endoscopy scoring methods and PCDAI in determining CD activity.Receiver operating characteristic curve analysis was performed to assess the diagnostic efficacy of laboratory indicators in predicting endoscopic activity.Results The PCDAI score showed a moderate positive correlation with the scores of Crohn's Disease Endoscopic Index of Severity(CDEIS)(rs=0.696,P<0.01),Simple Endoscopic Score for Crohn's Disease(SES-CD)(rs=0.680,P<0.01),Lewis Score(rs=0.540,P<0.01),and Capsule Endoscopy-Crohn's Disease Index(CE-CD)(rs=0.502,P<0.01).The consistency between all endoscopic scoring methods and PCDAI in determining CD activity was poor(Kappa=0.069-0.226).Erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),hematocrit(HCT),and serum albumin(ALB)levels showed a moderate correlation with the PCDAI score and the scores of colonoscopy scoring methods(CDEIS and SES-CD)(|rs|=0.581-0.725,P<0.01),but a weak correlation with the scores of capsule scoring methods(P<0.05).ESR and CRP had higher area under the curve(AUC)values in predicting disease activity based on PCDAI,CDEIS,SES-CD,and Lewis Score compared to HCT and ALB(P<0.05).Conclusions CDEIS,SES-CD,Lewis Score,and CE-CD can be used to evaluate disease activity in pediatric CD,but they do not fully correspond with disease activity assessed by PCDAI.Elevated levels of ESR and CRP can predict clinical and endoscopic disease activity in children with CD.
