Prognostic analysis of childhood T-lymphoblastic lymphoma treated with leukemia regimen
10.7499/j.issn.1008-8830.2311060
- VernacularTitle:儿童T淋巴母细胞淋巴瘤采用白血病方案治疗的预后分析
- Author:
Shu-Min HOU
1
;
Jing-Bo SHAO
;
Hong LI
;
Na ZHANG
;
Jia-Shi ZHU
;
Dan WANG
;
Pan FU
Author Information
1. 上海市儿童医院/上海交通大学医学院附属儿童医院血液肿瘤科,上海 200040
- Keywords:
T-lymphoblastic lymphoma;
Treatment;
Prognosis;
Child
- From:
Chinese Journal of Contemporary Pediatrics
2024;26(5):469-475
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the prognosis of childhood T-lymphoblastic lymphoma(T-LBL)treated with acute lymphoblastic leukemia(ALL)regimen and related influencing factors.Methods A retrospective analysis was performed for the prognostic characteristics of 29 children with T-LBL who were treated with ALL regimen(ALL-2009 or CCCG-ALL-2015 regimen)from May 2010 to May 2022.Results The 29 children with T-LBL had a 5-year overall survival(OS)rate of 84％±7％and an event-free survival(EFS)rate of 81％±8％.The children with B systemic symptoms(unexplained fever＞38° C for more than 3 days;night sweats;weight loss＞10％within 6 months)at initial diagnosis had a lower 5-year EFS rate compared to the children without B symptoms(P＜0.05).The children with platelet count＞400x109/L and involvement of both mediastinum and lymph nodes at initial diagnosis had lower 5-year OS rates(P＜0.05).There were no significant differences in 5-year OS and EFS rates between the children treated with CCCG-ALL-2015 regimen and those treated with ALL-2009 regimen(P＞0.05).Compared with the ALL-2009 regimen,the CCCG-ALL-2015 regimen reduced the frequency of high-dose methotrexate chemotherapy and the incidence rate of severe infections(P＜0.05).Conclusions The ALL regimen is safe and effective in children with T-LBL.Children with B systemic symptoms,platelet count＞400x109/L,and involvement of both mediastinum and lymph nodes at initial diagnosis tend to have a poor prognosis.Reduction in the frequency of high-dose methotrexate chemotherapy can reduce the incidence rate of severe infections,but it does not affect prognosis.
