Urinary protein and renal pathological features in children with immunoglobulin A vasculitis with nephritis and hypercoagulability
10.7499/j.issn.1008-8830.2309033
- VernacularTitle:儿童IgA血管炎肾炎伴高凝状态的尿蛋白和肾脏病理特征分析
- Author:
Meng-Ke BAI
1
;
Xiao-Qing YANG
;
Xiao-Feng MEI
;
Jin-Gang LI
;
Yue-Li YANG
;
Yan-Jie HUANG
Author Information
1. 河南中医药大学第一附属医院儿科医院/河南中医药大学儿科医学院,河南郑州 450000
- Keywords:
Immunoglobulin A vasculitis with nephritis;
Proteinuria;
Renal pathology;
Hypercoagulability;
Child
- From:
Chinese Journal of Contemporary Pediatrics
2024;26(2):164-168
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the association of hypercoagulability with urinary protein and renal pathological damage in children with immunoglobulin A vasculitis with nephritis(IgAVN).Methods Based on the results of coagulation function,349 children with IgAVN were divided into a hypercoagulability group consisting of 52 children and a non-hypercoagulability group consisting of 297 children.Urinary protein and renal pathological features were compared between the two groups,and the factors influencing the formation of hypercoagulability in children with IgAVN were analyzed.Results Compared with the non-hypercoagulability group,the hypercoagulability group had significantly higher levels of urinary erythrocyte count,24-hour urinary protein,urinary protein/creatinine,urinary immunoglobulin G/creatinine,and urinary N-acetyl-β-D-glucosaminidase(P<0.05).The hypercoagulability group also had a significantly higher proportion of children with a renal pathological grade of Ⅲ-Ⅳ,diffuse mesangial proliferation,capillary endothelial cell proliferation,or>25％ crescent formation(P<0.05).The multivariate logistic regression analysis showed that capillary endothelial cell proliferation and glomerular crescent formation>25％ were associated with the formation of hypercoagulability in children with IgAVN(P<0.05).Conclusions The renal injury in IgAVN children with hypercoagulability is more severe,with greater than 25％ crescent formation and increased proliferation of glomerular endothelial cells being important contributing factors that exacerbate the hypercoagulable state in IgAVN.[Chinese Journal of Contemporary Pediatrics,2024,26(2):164-168]
