Progress in application of three-dimensional models in colorectal cancer tumor microenvironment research
10.3969/j.issn.1000-4718.2024.11.023
- VernacularTitle:三维模型在结直肠癌肿瘤微环境研究中的应用进展
- Author:
Yabing LIANG
1
;
Ling YANG
;
Liya SU
Author Information
1. 内蒙古医科大学附属医院临床医学研究中心,内蒙古自治区医学细胞生物学重点实验室,内蒙古 呼和浩特 010050
- Keywords:
colorectal cancer;
organoids;
tumor microenvironment;
three-dimensional models;
co-culture
- From:
Chinese Journal of Pathophysiology
2024;40(11):2173-2178
- CountryChina
- Language:Chinese
-
Abstract:
Colorectal cancer is a common malignant tumor.Revealing the interaction between tumor cells and tu-mor microenvironment(TME)can provide new targets for the prevention or therapy of colorectal cancer.Three-dimensional models such as cell spheroids,organoids,organ chips,and three-dimensional printing have been widely used to simulate TME in colorectal cancer,which can better reproduce the structure and heterogeneity of TME.This paper reviews the progress in the application of three-dimensional models in TME research of colorectal cancer to provide references for future research.
