Significance of single-cell transcriptome sequencing in diagnosis,treat-ment and prognosis of multiple myeloma
10.3969/j.issn.1000-4718.2024.00.019
- VernacularTitle:单细胞转录组测序在多发性骨髓瘤诊治和预后中的意义
- Author:
Wenhui LIU
1
;
Tao WU
Author Information
1. 甘肃中医药大学第一临床医学院,甘肃 兰州 730030;中国人民解放军联勤保障部队第九四〇医院血液科,甘肃 兰州 730050
- Keywords:
single cell transcriptome sequencing;
multiple myeloma;
heterogeneity;
microenvironment
- From:
Chinese Journal of Pathophysiology
2024;40(8):1554-1558
- CountryChina
- Language:Chinese
-
Abstract:
Multiple myeloma(MM)is a plasma cell malignancy that is heterogeneous in both clinical and bio-logical settings.Despite extensive research and considerable progress in treatment,disease heterogeneity and relapse re-main a major challenge in MM treatment.Single-cell transcriptome sequencing(scRNA-seq)technology based on next-generation sequencing can detect the heterogeneity of tumor cells and bone marrow microenvironment at the single-cell level,thereby improving our understanding of MM diagnosis stratification,precise treatment and prognosis prediction.This article reviews the application of scRNA-seq in the diagnosis,treatment and prognosis of MM.
