Advances in effect of ferroptosis signaling on glycometabolic reprogramming of macrophages
10.3969/j.issn.1000-4718.2024.00.017
- VernacularTitle:铁死亡信号对巨噬细胞糖代谢重编程影响的研究进展
- Author:
Yang TANG
1
;
Yutong HU
;
Yang TAN
;
Ling LI
Author Information
1. 湖南省高等普通学校中药现代化研究重点实验室,湖南中医药大学药学院,湖南 长沙 410208
- Keywords:
Macrophages;
polarization;
ferroptosis;
glycometabolic reprogramming
- From:
Chinese Journal of Pathophysiology
2024;40(6):1134-1140
- CountryChina
- Language:Chinese
-
Abstract:
Ferroptosis is a new type of iron-dependent cell death and is involved in many biological processes.Multiple ferroptosis signals affect enzymes and metabolites during glucose metabolism,altering the metabolic pathways of macrophages.In addition,macrophages with different polarization phenotypes have different resistance to ferroptosis,which affects the occurrence and signal transmission of ferroptosis.Therefore,the important process of glucose metabolism in macrophages is targeted to regulate the sensitivity of macrophages to ferroptosis through energy metabolism.In this pa-per,we review the recent research progress on the effect of ferroptosis signaling on the reprogramming of glucose metabo-lism in macrophages and the regulatory effects of various compounds.
