Review of relationship between intestinal microflora and diabetic ulcers based on skin-cut axis
10.3969/j.issn.1000-4718.2024.06.020
- VernacularTitle:基于"皮-肠轴"理论探讨肠道菌群与糖尿病溃疡的关系
- Author:
Yanan ZHAO
1
;
Jianliang WEI
;
Qiu LI
;
Ming LIU
Author Information
1. 山东中医药大学附属医院周围血管病科,山东 济南 250000
- Keywords:
skin-gut axis;
intestinal flora;
diabetic ulcer
- From:
Chinese Journal of Pathophysiology
2024;40(6):1128-1133
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic ulcers are serious complications of diabetes mellitus and are characterized by delayed healing,susceptibility to infection,and inclination to amputation or sepsis.The mechanism of refractory diabetic ulcers is complex,and changes in microorganisms in the wound and the immune response produced by interactions with different cells participate in the repair of the wound.In recent years,researchers have proposed the concept of the"skin-gut axis"due to the physiological similarities and pathological correlation between the skin and intestinal tract;thus,skin diseases are considered to be closely related to gut flora.Therefore,this article reviews the relationship between intestinal microflo-ra and diabetic ulcers from the perspective of the interaction between skin and intestinal microorganisms.
