Roles of serotonin system in stress-induced impairment of hippocampal neurogenesis

VernacularTitle:5-羟色胺系统在应激损伤海马神经发生中的作用
Author: Le ZHU ¹ ; Shuying LIAO ; Yan ZENG ; Yufei MEI
Author Information

1. 武汉科技大学脑科学先进技术研究院,湖北武汉 430065
Keywords: 5-hydroxytryptamine; stress; neurogenesis; hippocampus
From: Chinese Journal of Pathophysiology 2024;40(5):944-949
CountryChina
Language:Chinese
Abstract: Stress is a common risk factor for emotional and cognitive dysfunction during mammalian growth and development.The hippocampal neurogenesis,which regulates the stress response,is highly susceptible to stress stimu-li.This review focuses on the pathomechanism underlying how stress stimuli affect hippocampal neurogenesis and explores the impact of aberrant 5-hydroxytryptamine(5-HT)system,including 5-HT,5-HT receptors and 5-HT neurons,on stress-induced impairment of hippocampal neurogenesis.By summarizing existing research,we aim to provide new ideas for the treatment of post-traumatic stress disorder and depression.