Innovations and challenges in intraperitoneal chemotherapy for peritoneal metastatic carcinoma
10.19401/j.cnki.1007-3639.2024.09.003
- VernacularTitle:腹膜转移癌腹腔化疗的创新与挑战
- Author:
Xinying FENG
1
;
Bing WANG
;
Peifeng LIU
Author Information
1. 上海交通大学医学院附属仁济医院,上海市肿瘤研究所,肿瘤系统医学全国重点实验室,上海 200032
- Keywords:
Peritoneal metastatic carcinoma;
Intraperitoneal chemotherapy;
Hyperthermic intraperitoneal chemotherapy;
Pressurized intraperitoneal aerosol chemotherapy;
Nano-drug;
Targeted therapy
- From:
China Oncology
2024;34(9):827-837
- CountryChina
- Language:Chinese
-
Abstract:
Peritoneal metastatic carcinoma refers to the spread of malignant tumors from the primary site to the peritoneum.It is commonly observed in the advanced stages of various cancer types,including gastric cancer,colorectal cancer,ovarian cancer and pseudomyxoma peritonei(PMP).Peritoneal metastatic carcinoma seriously impair human health due to their high recurrence and mortality rates,and palliative treatment based on chemotherapy is usually provided after radical surgery or in the advanced stage of peritoneal metastases.The difficulties in the treatment of peritoneal metastatic carcinoma are the lack of targeted drugs and the difficulty of drugs to cross the blood-peritoneal barrier,resulting in poor systemic effects.Intraperitoneal chemotherapy,as an important therapeutic means,has a broad application prospect in the treatment of peritoneal metastatic carcinoma.In recent years,innovations in intraperitoneal chemotherapy techniques such as hyperthermic intraperitoneal chemotherapy(HIPEC),pressurized intraperitoneal aerosol chemotherapy(PIPAC)and the development of novel drugs have significantly improved patients'quality of life.The development of novel drugs has significantly improved patient survival.However,the diversity and complexity of these diseases have led to clinical variability and uncertainty in the efficacy of intraperitoneal chemotherapy in terms of treatment strategies such as mode of administration,drug type and dose.Although evidence-based guidelines and recommended treatment strategies have been developed,there is a need to further support these regimens through additional clinical trials and higher levels of evidence-based medicine.This review summarized the development history and recent advances in intraperitoneal chemotherapy,compared and analyzed the treatments such as surgery combined with traditional IPC,HIPEC and PIPAC,and summarized the research progress of recently conducted intraperitoneal chemotherapy techniques;moreover,in terms of the clinical application of intraperitoneal chemotherapy techniques,this paper elaborated on its use in diseases such as gastric cancer,colorectal cancer,gynecological oncology,PMP,cholangiocarcinoma and pancreatic cancer.For the limitations of intraperitoneal chemotherapy technology,it is proposed that the innovative development of nanomedicine is expected to provide a safer and more effective option for the treatment of peritoneal metastatic carcinoma.In conclusion,this review summarized the latest progress,shortcomings and future development of intraperitoneal chemotherapy,with the aim of providing a feasible direction for more effective clinical treatment of peritoneal metastatic carcinoma.
