Meta analysis of the effect of low microbiological diet in preventing infection in patients with malignant tumors during the agranulocytosis after chemotherapy
10.3760/cma.j.cn115682-20210721-03228
- VernacularTitle:应用低微生物饮食预防恶性肿瘤化疗后粒细胞缺乏症患者感染效果的Meta分析
- Author:
Qianqian ZHANG
1
;
Wenjun XIE
;
Junjie LI
;
Qingsong LIN
;
Chunhui XU
;
Guoqing ZHU
Author Information
1. 中国医学科学院血液病医院（中国医学科学院血液学研究所），实验血液学国家重点实验室，国家血液系统疾病临床医学研究中心骨髓增生异常综合征诊疗中心，天津 300020
- Keywords:
Low microbiological diet;
Agranulocytosis;
Infection;
Meta-analysis
- From:
Chinese Journal of Modern Nursing
2021;27(36):4983-4990
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To systematically evaluate the effects of a low-microbiological diet on the incidence of infection in cancer patients with agranulocytosis.Methods:The Cochrane Library, PubMed, Embase, Web of Science, CNKI, China Biology Medicine disc (CBM) , Wanfang Database and VIP database were searched by computer. After two researchers independently carried out literature screening, data extraction and evidence quality evaluation, RevMan 5.3 software was used for Meta-analysis.Results:A total of 7 studies were included, including 5 RCT studies and 2 retrospective case-control trials. Meta-analysis results showed that in retrospective controlled studies [ RR=1.29, 95% CI (1.10, 1.50) , P=0.002], and between different subjects (transplanted and non-transplanted patients) [ RR=1.21, 95% CI (1.08, 1.36) , P=0.001], the incidence of infection in the routine diet group was lower than that in the low-microbial diet group. In the prospective randomized controlled study, there was no statistically significant difference in the infection rate between the two groups [ RR=1.08, 95% CI (0.92, 1.28) , P=0.340]. In terms of infection-related mortality, there was no statistically significant difference between the two groups [ RR=1.06, 95% CI (0.76, 1.47) , P=0.750]. Conclusions:Compared with patients with unrestricted diet, the low-microbial diet does reduce the infection rate and infection-related mortality of patients. Dietary restrictions for patients with granulocytic cancer may be appropriately relaxed, and a focus on safe food purchase and handling and good hand hygiene may provide better infection prevention for patients with agranulocytosis.
