Changes in 12 cytokines in the cerebrospinal fluid of patients with CNS infections and their clinical significance
10.19845/j.cnki.zfysjjbzz.2024.0175
- VernacularTitle:中枢神经系统感染患者脑脊液中12种细胞因子的变化及临床意义
- Author:
Yue ZHANG
1
;
Lu ZHENG
;
Yuanyuan CHEN
Author Information
1. 徐州市中心医院检验科,江苏 徐州 221000
- Keywords:
Cerebrospinal fluid;
Cytokines;
Central nervous system infection;
Multiplexed microsphere-based flow cytometry
- From:
Journal of Apoplexy and Nervous Diseases
2024;41(10):923-927
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine the pattern of changes in 12 cytokines(IFN-α,IFN-γ,TNF-α,IL-1β,IL-2,IL-4,IL-5,IL-6,IL-8,IL-10,IL-12p70,and IL-17)in the cerebrospinal fluid(CSF)of patients with central nervous system(CNS)infections and their clinical significance.Methods Fifty-two patients clinically diagnosed with CNS infec-tions at our hospital were enrolled in the study.CSF was collected for CSF analysis,biochemical analysis,and cytology.Changes in the CSF levels of 12 cytokines were measured by flow cytometry.Results Only IL-5,IL-6,and IL-8 were sig-nificantly increased in the CSF,and the corresponding positive rates were 23.08%,42.31%,and 96.15%,respectively.High levels of IL-5,IL-6,and IL-8 were positively correlated with white blood cell(WBC)count and neutrophil percent-age but negatively correlated with lymphocyte percentage in the CSF.Consistent with the WBC count,IL-5,IL-6,and IL-8 levels in the CSF were significantly decreased after effective treatment.Conclusion The levels of IL-5,IL-6,and IL-8 in CSF can be used as potential markers for the diagnosis,treatment,and severity assessment of CNS infections.
