Association between milk fat globule-epidermal growth factor 8 with Alzheimer disease
10.19845/j.cnki.zfysjjbzz.2024.0132
- VernacularTitle:乳脂球表皮生长因子8与阿尔茨海默病的关联
- Author:
Zihao ZHANG
1
;
Yangke ZHU
;
Yujing WANG
Author Information
1. 青岛大学,青岛大学医学部,青岛市市立医院神经内科,山东 青岛 266071
- Keywords:
Milk fat globule-epidermal growth factor 8;
Alzheimer disease;
Dementia;
Amyloid β-protein 42
- From:
Journal of Apoplexy and Nervous Diseases
2024;41(8):686-691
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between milk fat globule-epidermal growth factor 8(MFG-E8)and Alzheimer disease(AD).Methods The Alzheimer's Disease Neuroimaging Initiative database was used,and a multiple linear regression analysis was used to investigate the association of MFG-E8 with the pathological markers of AD and brain structure and perform subgroup analyses.The mixed-effects model was used to investigate the longitudinal changes in MFG-E8 with AD pathological markers and brain structure,and a mediation analysis was used to investigate the potential association of MFG-E8 with AD pathology and brain structure.Results A total of 377 individuals were en-rolled in the study.The level of MFG-E8 was positively correlated with the concentrations of amyloid β-protein 42(Aβ42),tau protein,and phosphorylated tau protein in cerebrospinal fluid,and subgroup analyses showed that the correlation of MFG-E8 with the concentrations of AD pathological markers and lateral ventricular volume in male individuals,the elderly popula-tion,and the individuals carrying the APOE4 gene was consistent with that in the overall population.Longitudinal studies showed that during follow-up,the increase in MFG-E8 level was significantly associated with enlarged lateral ventricle volume.In addition,MFG-E8 could alter lateral ventricle volume by affecting the level of Aβ42.Conclusion MFG-E8 is associated with AD and may influence lateral ventricular volume through AD pathological markers.
