Research advances in the association of natriuretic peptides and cyclic guanosine monophosphate with acute isch-emic stroke

VernacularTitle:利钠肽、cGMP与急性缺血性脑卒中的相关研究进展
Author: Jiaren LI ¹ ; Jiayu LIU ; Jiale ZHANG
Author Information

1. 包头医学院生理学教研室,内蒙古包头 014040
Keywords: Natriuretic peptides; Acute ischemic stroke; Cyclic guanosine monophosphate
From: Journal of Apoplexy and Nervous Diseases 2024;41(5):470-475
CountryChina
Language:Chinese
Abstract: Natriuretic peptides(NPs)are closely associated with acute ischemic stroke(AIS),and previous studies have shown that NPs have the beneficial effects of promoting vasodilation and inhibiting inflammation and apoptosis.The beneficial cardiovascular effects of atrial natriuretic peptide(ANP)and brain natriuretic peptide(BNP)are associated with the natriuretic peptide receptor A/cyclic guanosine monophosphate(cGMP)signaling pathway.With the discovery of C-type natriuretic peptide(CNP)and its dependent receptor natriuretic peptide receptor B in brain tissue,NPs provide new ideas for the diagnosis and treatment of AIS.Recent studies have confirmed the beneficial effects of ANP,BNP,CNP,and their homologous receptors on neuronal damage induced by AIS;however,the specific mechanism of pathways mediated by NPs remains unknown.This article summarizes the studies on NPs,cGMP,and AIS,in order to provide a ref-erence for subsequent studies on NPs in AIS.