Advances in T Cell Mechanoimmunology
10.16156/j.1004-7220.2024.05.002
- VernacularTitle:T细胞力学免疫学研究进展
- Author:
Songfang WU
1
;
Jizhong LOU
Author Information
1. 中国科学院 生物物理研究所,表观遗传调控与干预重点实验室,北京 100101
- Keywords:
T cell receptor;
catch bond;
mechanotransduction;
single-molecule force spectroscopy;
cancer immunotherapy;
mechanoimmunology
- From:
Journal of Medical Biomechanics
2024;39(5):796-805
- CountryChina
- Language:Chinese
-
Abstract:
T cells play an essential role in adaptive immunity,and the specific recognition of antigens by T cell receptors(TCRs)is the key in initiating anti-tumor and antiviral immune responses.Recent studies have demonstrated that force plays an important regulatory role in T cell immune responses,laying the foundation for the emerging field of mechanoimmunology.In this review,the mechanisms by which force assists TCRs in distinguishing between specific antigens and non-specific antigens,as well as the critical role force plays in initiating TCR transmembrane signaling and triggering T cell activation are mainly discussed.The novel biophysical single-molecule tools and advanced imaging techniques that can deeply reveal the importance of mechanical forces at the molecular and/or cellular level are summarized.Based on the research results of domestic and foreign expert teams,combined with the research work of our team,this review summarizes and discusses the role of force in T cell function,so as to provide a system framework for deeply understanding the cutting-edge hotspots in the field of mechanoimunology and exploring new research directions.
