Research Progress and Prospect of Small-Caliber Artificial Blood Vessels

VernacularTitle:小口径人工血管的研究现状及展望
Author: Xin WU ¹ ; Lei HOU ; Feng XU
Author Information

1. 广西医科大学再生医学与医用生物资源开发应用省部共建协同创新中心;广西再生医学重点实验室,南宁 530021
Keywords: small-caliber artificial blood vessels; biocompatibility; endothelialization; compliance
From: Journal of Medical Biomechanics 2024;39(2):355-360
CountryChina
Language:Chinese
Abstract: In recent years,the incidence of cardiovascular diseases has been gradually increasing,leading to a growing demand for regenerative blood vessels in clinic.Currently,large-caliber artificial blood vessels(diameter＞6 mm)have been successfully applied in clinical practice.However,small-caliber artificial blood vessels(diameter＜6 mm)still face challenges in long-term patency rates after transplantation due to thrombosis,intimal hyperplasia,inflammatory reactions,and poor compliance which leads to hemodynamic changes.Achieving rapid endothelialization,inhibiting thrombus formation,and matching the compliance of autologous vessels remain key factors to be addressed.This article provides a brief overview of commonly used materials and techniques for preparing small-caliber artificial blood vessels,with a focus on discussing strategies to improve biocompatibility and compliance.Furthermore,future research work is also prospected.