Optimization of Extraction Process for Huangshen Changshu Lotion by Response Surface Methodology

VernacularTitle:响应面法优化黄参肠舒洗剂的提取工艺
Author: Dan LI ¹ ; Li WAN ; Shasha ZHANG ; Xianya QIN
Author Information

1. 湖北省妇幼保健院药学部,武汉 430070
Keywords: Huangshen Changshu lotion; Rhein; Emodin; Flash extraction; Response surface methodology
From: Herald of Medicine 2024;43(11):1844-1848
CountryChina
Language:Chinese
Abstract: Objective To optimize of flash extraction parameters for Huangshen Changshu lotion based on response surface methodology.Methods Using flash extraction technology,the comprehensive scores of the extraction amount of rhein,emodin,and dry cream yield were used as evaluation indicators.The Box Behnken Design program provided by Response Surface Design Expert software was used for experimental design to optimize the optimal process parameters for flash extraction of Huangshen Changshu lotion,and compared with traditional extraction processes.Results The optimal extraction process parameters for Huangshen Changshu lotion flash extraction are as follows:a rotational speed of 4 000 r·min-1,a solid-liquid ratio of 1:25(g·mL-1),and an extraction time of 100 s.Conclusion The flash extraction process technology for Huangshen Changshu lotion established through research is feasible and has obvious advantages compared to traditional extraction processes,providing a research foundation for new extraction processes and subsequent drug development of Huangshen Changshu lotion.