Clinical Characterization of 53 Cases of Carbapenem-Resistant Enterobacteriaceae Bacteria Bloodstream Infections
10.3870/j.issn.1004-0781.2024.10.007
- VernacularTitle:53例耐碳青霉烯类肠杆菌血流感染临床特征分析
- Author:
Ying LIU
1
;
Pujiao SUN
;
Kaiju XU
;
Renguo YANG
;
Xingxiang YANG
Author Information
1. 四川省医学科学院·四川省人民医院感染科,成都 610072
- Keywords:
Carbapenem-resistant Enterobacteriaceae;
Bloodstream infection;
Clinical characteristics
- From:
Herald of Medicine
2024;43(10):1578-1582
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical characteristics and treatment strategies of patients with Carbapenem-resistant Enterobacteriaceae(CRE)bloodstream infection.Methods A retrospective analysis was conducted on demographic information,microbiological data,and clinical characteristics of patients with CRE bloodstream infections in Sichuan Provincial People's Hospital from September 2018 to December 2021.Results A total of 53 cases of CRE bloodstream infections were identified,with a treatment failure rate of 47.2% .Patients with bloodstream infections caused by carbapenem-resistant Klebsiella pneumoniae(CRKP)had a worse prognosis(P<0.05).Patients with treatment failure showed higher levels of procalcitonin,C-reactive protein,lactate dehydrogenase,and prolonged prothrombin time,along with lower levels of globulin(P<0.05).Among the 53 patients included in the outcome analysis following drugs,there was no statistically significant difference between monotherapy(n=15)and combination therapy(n=38)(P>0.05).Treatment regimens containing tigecycline were not superior to other strategies without tigecycline(P>0.05).Univariate analysis results indicated that the prognosis of CRE bloodstream infection was associated with endotracheal intubation,central venous catheterization,bacterial species which lead infection,comorbidities of the hepatobiliary system,and infection occurring after ICU admission(P<0.05).Health issues involving the hepatobiliary system and ICU-onset admission were independent risk factors for the prognosis of CRE bloodstream infection(P<0.05).Conclusion Patients with CRE bloodstream infections have a high mortality rate,and those with elevated procalcitonin and C-reactive protein levels indicate a poor prognosis.The use of tigecycline in combination or alone may not be the optimal treatment choice for CRE-related BSI.
