Research Progress on the Inhibition of Helicobacter Pylori Urease by Plant-derived Flavonoids
10.3870/j.issn.1004-0781.2024.08.021
- VernacularTitle:植物源黄酮类化合物对幽门螺杆菌脲酶抑制作用的研究进展
- Author:
Wenyan XU
1
;
Ganrong HUANG
;
Lijuan LIAO
;
Jiazi LUO
;
Liang HUANG
;
Yanqiang HUANG
Author Information
1. 右江民族医学院,广西病原微生物耐药防控科技创新合作基地,广西高校耐药微生物感染防治研究重点实验室,百色 533000
- Keywords:
Flavonoids;
Helicobacter pylori;
Urease;
Antibacterial effect
- From:
Herald of Medicine
2024;43(8):1309-1314
- CountryChina
- Language:Chinese
-
Abstract:
As a key enzyme in the nitrogen cycle,urease is not only a nitrogen source for the growth of organisms,but also a virulence factor found in various pathogenic bacteria.The urease produced by Helicobacter pylori(H.pylori)plays an im-portant role in the colonization and survival of H.pylori.However,H.pylori infections are closely associated with gastrointestinal diseases such as intestinal metaplasia,active gastritis,peptic ulcer and gastric cancer.With the increasing of drug-resistant strains,there is an urgent need for effective and safe new drugs,so H.pylori has become one of the most frequently studied ure-ase-producing bacteria.Urease has also received considerable attention as a potential target for antibacterial drugs.Medicinal plants with high safety have been proven to have therapeutic potential,and many natural plant extracts have become the inspira-tion and starting point of new drug development;previous studies have also found that many naturally occurring flavonoids have anti-urease activity.Therefore,this review summarizes the effects of inhibiting some plant-derived flavonoids on H.pylori urease.According to their origins,structural characteristics,and possible mechanism of action,we seek and develop plant-derived com-pounds with the specificity of anti-H.pylori,which can provide references for developing clinical drug candidates.
