Causal Relationship Between Immune Cells and Risk of Inflammatory Joint Diseases:A Mendelian Randomization Study
10.11969/j.issn.1673-548X.2024.08.020
- VernacularTitle:免疫细胞与炎性关节病风险的因果关系:一项孟德尔随机化研究
- Author:
Hui LIU
1
;
Yuqi ZHU
;
Yingjun ZHAO
Author Information
1. 100040 北京,中国中医科学院眼科医院骨科
- Keywords:
Immune cells;
Ankylosing spondylitis;
Mendelian randomization;
Osteoarthritis;
Gout
- From:
Journal of Medical Research
2024;53(8):102-106,114
- CountryChina
- Language:Chinese
-
Abstract:
Objective A two-sample Mendelian randomization approach was used to explore the causal relationship between im-mune cells and the risk of inflammatory joint diseases.Methods A dataset of 731 immune cells and osteoarthritis,ankylosing spondyli-tis,gout,and psoriatic arthritis was obtained from the Finngen database and the GWAS catalog database.The causal relationship between immune cells and osteoarthritis was explored using inverse variance weighting,weighted median and MR-Egger methods,and the stabili-ty and reliability of the research results were evaluated using Cochran's Q test,MR-Egger regression,MR-PRESSO,Leave one out method,and Meta-analysis.Results A total of 45 immune cells were obtained with osteoarthritis,35 immune cells with ankylosing spondylitis,29 immune cells with gout,and 36 immune cells with psoriatic arthritis in a potential causal relationship(P＜0.05).There was a significant causal relationship between HLA DR on CD14-CD16+monocyte and ankylosing spondylitis(P＜6.8 × 10-5),and the results were stable,but Meta-analysis showed that the causal relationship was not significant(OR=1.00,95％CI:1.00-1.00).Conclusion This study preliminarily reveals the causal relationship between immune cells and inflammatory joint diseases represented by ankylosing spondylitis from the perspective of genetics,and provides an important theoretical basis for future precision medicine and indi-vidualized treatment.
