Predictive Value of Iris and Leptin Levels in Postmenopausal Osteoporosis
10.11969/j.issn.1673-548X.2024.06.009
- VernacularTitle:鸢尾素和瘦素水平对绝经后骨质疏松症的预测价值
- Author:
Zhijie YANG
1
;
Xiancan LIN
;
Jianjun WU
Author Information
1. 510006 广州中医药大学第三临床医学院
- Keywords:
Postmenopausal osteoporosis;
Irisin;
Leptin;
ROC curve
- From:
Journal of Medical Research
2024;53(6):40-43,10
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the predictive value of irisin and leptin levels in postmenopausal osteoporosis(PMOP).Methods A total of 64 postmenopausal women treated in the outpatient department of the Third Affiliated Hospital of Guangzhou Univer-sity of Chinese Medicine from November 2019 to January 2021 were collected as study subjects,and they were divided into osteoporosis group(n=33)and non-osteoporosis group(n=31).Baseline data and levels of irisin and leptin in the two groups were compared.Pearson correlation analysis was used to study the correlation between irisin,leptin levels and baseline data.The predictive efficacy of iri-sin and leptin levels in PMOP was evaluated by receiver operating characteristic(ROC)curve.Results The levels of irisin and leptin in osteoporosis group were lower than those in non-osteoporosis group,the difference was statistically significant(P＜0.01);Pearson cor-relation analysis showed that irisin and leptin levels were positively correlated with lumbar bone density and overall bone density(P＜0.01).ROC curve analysis showed that area under the curve(AUC)of irisin was 0.706,the AUC of leptin was 0.702;and the predic-tive critical value was determined:irisin level＞224.88pg/ml,the sensitivity was 58.06％,the specificity was 87.91％;leptin level＞13.93μg/L,the sensitivity was 61.29％,the specificity was 78.79％.Conclusion Irisin and leptin levels have good predictive value for PMOP.The serum irisin level＜224.88pg/ml and leptin level＜13.93μg/L in postmenopausal women may have the possibility of bone mass loss.
