A case of acute kidney injury caused by oral sodium phosphate
10.12173/j.issn.1005-0698.202406037
- VernacularTitle:口服磷酸钠盐致急性肾损伤1例
- Author:
Qin PENG
1
;
Wenfeng WU
;
Huiyi WU
Author Information
1. 南方医科大学南方医院临床药学中心(广州 510515);川北医学院第二临床医学院/南充市中心医院临床药学科(四川南充 637100)
- Keywords:
Sodium phosphate oral solution;
Acute kidney injury;
Hypertension;
Adverse drug reaction
- From:
Chinese Journal of Pharmacoepidemiology
2024;33(10):1183-1188
- CountryChina
- Language:Chinese
-
Abstract:
A 50-year-old hypertension male without high-risk factors related to acute kidney injury(AKI),took 90 mL oral sodium phosphates(OSP)solution for intestinal cleansing before the colonoscopy.After medication,severe diarrhea and vomiting appeared,with decreased blood pressure,anuria for 24 h,and serum creatinine increased from 87 μmol·L-1 to 398 μmol·L-1.Renal biopsy showed blue-purple calcium phosphate crystals were deposited in the renal tubules,the brush border disappeared and epithelial cell necrosis was necrotic or shed.The patient was diagnosed with AKI.According to Naranjo's Assessment Scale for adverse reactions,AKI was"probably"associated with the oral sodium phosphate.Subsequently,the patient was treated with prednisone acetate tablets,and serum creatinine was decreased significantly to 158 μmol·L-1 2 months later.This case suggests that sodium phosphate preparation should be used with caution in hypertensive patients to avoid AKI.
