Analysis of a case of acute febrile neutrophilc dermatosis caused by hydroxychloroquine sulfate
10.12173/j.issn.1005-0698.202404024
- VernacularTitle:硫酸羟氯喹致急性发热性嗜中性皮病1例分析
- Author:
Juanjuan MA
1
;
Donghong TAO
;
Qihua WAN
Author Information
1. 西宁市第一人民医院临床药学科(西宁 810000)
- Keywords:
Hydroxychloroquine sulfate;
Acute febrile neutrophilic dermatosis;
Adverse reactions
- From:
Chinese Journal of Pharmacoepidemiology
2024;33(7):830-834
- CountryChina
- Language:Chinese
-
Abstract:
A 48-year-old female patient was treated with hydroxychloroquine sulfate and methotrexate for rheumatoid arthritis.After two weeks,tender erythema and papules appeared on the trunk and limbs,accompanied by fever.Skin biopsy was suggestive of neutrophilic infiltration in the superficial mesodermal layer of the dermis.After hydroxychloroquine sulfate withdrawal and 18 days of methylprednisolone sodium succinate and halometasone cream treatment,she improved and was diagnosed with acute febrile neutrophilic dermatosis.By correlation analysis,the causal relationship between acute febrile neutrophilic dermatosis and hydroxychloroquine sulfate was evaluated as"most likely",which had not been reported in China.The pathogenesis of hydroxychloroquine sulfate-induced acute febrile neutrophilic dermatosis may be related to elevated granulocyte-colony stimulating factor levels,abnormal cytokine regulation,and genetic susceptibility.Discontinuation of the suspected drug and application of glucocorticoids are currently the most effective treatment.
