Linezolid-induced multiple adverse reactions:a case report
10.12173/j.issn.1005-0698.202403054
- VernacularTitle:利奈唑胺致多重不良反应1例报道
- Author:
Wanli TAN
1
;
Huijuan YAO
Author Information
1. 上海交通大学医学院附属新华医院临床药学部(上海 200092);广安市人民医院药学部(四川广安 638500)
- Keywords:
Linezolid;
Olfactory dysfunction;
Myelosuppression;
Lactic acidosis;
Optic neuropathy;
Adverse drug reaction
- From:
Chinese Journal of Pharmacoepidemiology
2024;33(6):714-720
- CountryChina
- Language:Chinese
-
Abstract:
A 69-year-old male patient with cervical discitis received linezolid treatment for two months.The white blood cell count,red blood cell count,hemoglobin,and platelet count of the patient were all below normal ranges.Simultaneously,the blood lactate level increased to 2.6 mmol·L-1,and he experienced blurred vision and worsening olfactory dysfunction.After discontinuing linezolid,treatment with erythropoietin injections and Diyu Shengbai tablets was initiated.The blood parameters gradually returned to normal,as did the lactate level,and the vision and olfactory impairment of the patient were improved.Using Naranjo's assessment scale indicated that the adverse drug reaction was"probably relevant"such as pancytopenia,elevated lactate,visual disturbances,and exacerbated olfactory dysfunction,were likely to be due to linezolid.While severe adverse reactions to linezolid typically manifest in isolation,clinicians and pharmacists should remain vigilant for the simultaneous occurrence of multiple adverse reactions.The onset of adverse reactions is associated with the duration of therapy,dosage,and the patient's baseline health.Monitoring of drug levels and relevant parameters during treatment can help in early detection of such adverse reactions.
