Dosimetric study of volumetric modulated arc therapy for pediatric Wilms'tumor under flattening filter free and flattening filter modes
10.19745/j.1003-8868.2024073
- VernacularTitle:非均整模式与均整模式下儿童肾母细胞瘤容积调强放疗的剂量学研究
- Author:
Zhan-Quan LEI
1
Author Information
1. 福建省儿童医院(上海儿童医学中心福建医院)放疗科,福州 350014
- Keywords:
Wilms'tumor;
flattening filer free mode;
flattening filter mode;
volumetric modulated arc therapy;
dosimetric parameter
- From:
Chinese Medical Equipment Journal
2024;45(4):70-73
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the dosimetric differences in volumetric modulated arc therapy(VMAT)for pediatric Wilms'tumor under flattening filter(FF)and flattening filter free(FFF)modes.Methods Ten children with Wilms'tumor who received radiotherapy at some hospital from August 2022 to October 2023 were selected retrospectively,for whom the VMAT plans were designed under FF and FFF modes.The two kinds of plans were compared in terms of planning target volume(PTV)dosimetric parameters,exposure dose to organ at risk(OAR),monitor units,gamma pass rate and treatment time.Results The FFF plan behaved significantly better than the FF plan in D2,D98 and HI(P＜0.05);the two kinds of plans had no statistically obvious differences in D50 and CI(P＞0.05).The FFF plan gained advantages over the FF plan in Dmean,V5 and V10 of the contralateral kidney,Dmean,V5 and V10 of the liver and Dmax of the spinal cord,and the differences were statistically significant(P＜0.05).The FF plan outperformed the FFF plan in gamma pass rate and monitor units,while the FFF plan had the treatment time shorter than that of the FF plan,and the differences were statistically significant(P＜0.05).The two kinds of VMAT plans both had the gamma pass rates higher than 95％.Conclusion The VMAT plans under both FF and FFF modes meet clinical treatment requirements,and the FFF mode has advantages over the FF mode in terms of PTV dose distribution,exposure dose to OAR and treatment time,which contribute to enhancing the treatment outcome and cooperation of the children.[Chinese Medical Equipment Journal,2024,45(4):70-73]
