Clinical features and research status of the pleomorphic adenoma of the lacrimal gland
10.3760/cma.j.cn115989-20210423-00271
- VernacularTitle:泪腺多形性腺瘤的临床特征及研究现况
- Author:
Yaqi SHAO
1
;
Jianmin MA
Author Information
1. 首都医科大学附属北京同仁医院 北京同仁眼科中心 北京市眼科学与视觉科学重点实验室，北京 100730
- Keywords:
Pleomorphic adenoma of the lacrimal gland;
Histopathology;
Imaging;
Molecular mechanisms;
Malignant transformation mechanism;
Treatment;
Prognosis
- From:
Chinese Journal of Experimental Ophthalmology
2024;42(11):1036-1042
- CountryChina
- Language:Chinese
-
Abstract:
Pleomorphic adenoma of the lacrimal gland (LGPA) is the most common epithelial lacrimal gland tumor, mainly occurring in the orbital lacrimal gland.The specific mechanism of its occurrence is unknown.The average onset age of LGPA is 39.5 years, and its clinical manifestations are usually lachrymal mass and exophthalmos, which are painless.If patients feel pain, malignant lesions should be considered.Imaging studies are of great value in the diagnosis of LGPA and can also be an important reference for the formulation of the surgical plan.To avoid capsule damage and tumor spillage, incisional biopsy isn't performed before surgery in LGPA.The treatment of LGPA is intact capsule excision.The risk of recurrence and malignant transformation is closely related to whether the tumor can be completely removed.This article reviews the clinical manifestation, histopathological changes, medical imaging changes, molecular mechanisms of tumor occurrence and development, malignant transformation mechanism, treatment and prognosis of LGPA in recent years from domestic and foreign research results, expecting to provide some references for the diagnosis and treatment of LGPA.
