Role of retinal pigment epithelium-derived extracellular vesicles in the pathogenesis of age-related macular degeneration
10.3760/cma.j.cn115989-20230626-00022
- VernacularTitle:视网膜色素上皮细胞来源的细胞外囊泡在年龄相关性黄斑变性发病机制中的作用
- Author:
Youge GAO
1
;
Yange WANG
;
Zongming SONG
Author Information
1. 河南大学人民医院眼科 河南省人民医院眼科 河南省立眼科医院 河南省眼科与视觉科学重点实验室 河南省医学科学院眼科研究所，郑州 450003
- Keywords:
Retinal pigment epithelium;
Extracellular vesicles;
Age-related macular degeneration;
Oxidative stress;
Inflammation;
Neovascularization
- From:
Chinese Journal of Experimental Ophthalmology
2024;42(9):876-880
- CountryChina
- Language:Chinese
-
Abstract:
Age-related macular degeneration (AMD) is one of the main causes of irreversible vision loss in the elderly worldwide.Its main pathological features are the degeneration of retinal pigment epithelium (RPE) and the irreversible damage or loss of photoreceptor cells.Extracellular vesicles (EVs) are a class of heterogeneous nanovesicles with lipid bilayer membranes, including exosomes, microvesicles and apoptotic bodies, which exert biological effects by transmitting molecules such as RNA and protein.In this review, RPE-derived extracellular vesicles (RPE-EVs) are involved in the regulation of oxidative stress, inflammation, and neovascularization in AMD.RPE-EVs derived Apaf1, HDAC6, miR-494-3p, miR-138-5p, miR-21, miR-543 and miR-302a-3p can be used as candidate molecular targets for the diagnosis and treatment of AMD, but their mechanisms of action have not been elucidated.Due to the unique advantages of high biocompatibility, low immunogenicity, low toxicity, targeting, stability, and specificity of RPE-EVs, it is necessary to further study the role of RPE-EVs in the pathogenesis of AMD, and focus on the role of RPE-EVs in the diagnosis and treatment of AMD, so as to realize the clinical transformation of RPE-EVs, and open up new ways for the diagnosis and treatment of AMD.
