Research progress on the association between environmental pollution and diabetic retinopathy
10.3760/cma.j.cn115989-20211228-00719
- VernacularTitle:环境污染与DR的关系研究进展
- Author:
Tianyi YUAN
1
;
Haidong ZOU
Author Information
1. 上海交通大学医学院附属第一人民医院 上海市眼病防治中心/上海市眼科医院 上海市眼科疾病精准诊疗工程技术研究中心，上海 200080
- Keywords:
Diabetic retinopathy;
Environmental pollution;
Air pollution;
Heavy metal pollution;
Chemical pollution
- From:
Chinese Journal of Experimental Ophthalmology
2024;42(8):758-762
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic retinopathy (DR) is a chronic progressive retinal disease caused by sustained hyperglycemia, which has become one of the leading causes of severe visual impairment and blindness in China.Nevertheless, factors that contribute to the pathogenesis and progression of DR remain unclear.Previous research has revealed that some environmental pollutants including particulate matter, H 2S, cobalt, cadmium, cesium, phthalic acid esters, methylglyoxal and 2-piperidone can potentially increase the risk or progression of DR through the related pathways of oxidative stress, inflammatory response and vascular endothelial growth factor.To clarify the causal and dose-response relationship between exposure to environmental pollutants and DR, further investigation is required to explore the detailed mechanisms.Moreover, longitudinal studies with quantified measurements of environmental exposures are also needed.This article reviews recent epidemiological research and the potential mechanisms of correlation between DR and air pollution, heavy metal pollution and chemical pollution.
