Research progress on the biomechanical properties of trabecular network in the pathogenesis of glaucoma
10.3760/cma.j.cn115989-20210721-00421
- VernacularTitle:小梁网生物力学性能在青光眼发病机制中的研究进展
- Author:
Qianwen BU
1
;
Xiaojing PAN
Author Information
1. 山东第一医科大学（山东省医学科学院） 山东省眼科研究所 山东省眼科学重点实验室－省部共建国家重点实验室培育基地 青岛眼科医院，青岛 266071
- Keywords:
Trabecular meshwork;
Glaucoma;
Biomechanics;
Aqueous outflow;
Conduction path
- From:
Chinese Journal of Experimental Ophthalmology
2024;42(6):564-568
- CountryChina
- Language:Chinese
-
Abstract:
Trabecular network, as the first resistance site of the aqueous humor outflow pathway, plays an important role in the regulation of intraocular pressure.Alteration of the biomechanical properties of trabecular meshwork may affect the aqueous humor outflow of filtration system and is of great importance in the pathogenesis of primary open-angle glaucoma (POAG).There may be a correlation between intraocular pressure and mechanical properties of trabecular meshwork, but the current research shows that the mechanical properties of trabecular meshwork are mainly affected by genetic and gene mutation, age, extracellular matrix and cytoskeleton components, lysophosphatidic acid, low dexamethasone, Rho-related protein kinase inhibitors and other factors.In addition, other intraocular diseases may affect the mechanical properties of trabecular meshwork.Under mechanical traction, the strain produced by trabecular meshwork may indicate the molecular mechanism of aqueous outflow, the regulation mechanism of outflow pathway and the pathogenesis of POAG under high intraocular pressure.The biomechanical properties of trabecular meshwork will provide a more powerful theoretical and experimental basis for the early diagnosis and treatment of glaucoma.This paper reviews the status of research on trabecular meshwork biomechanical measurement methods, influencing factors and sensing pathways of trabecular meshwork cell, in order to further elaborate the etiology, pathogenesis and treatment of POAG.
