Advances in research on rodent models of glaucoma
10.3760/cma.j.cn115989-20211026-00585
- VernacularTitle:啮齿动物青光眼模型研究进展
- Author:
Zhi XIE
1
;
Ting CAO
;
Xu ZHANG
Author Information
1. 南昌大学附属眼科医院 江西省眼科学与视觉科学研究所 江西省眼科学重点实验室，南昌 330006
- Keywords:
Glaucoma;
Disease models, animal;
Rodentia;
Intraocular pressure;
Transgenic mice
- From:
Chinese Journal of Experimental Ophthalmology
2024;42(6):557-563
- CountryChina
- Language:Chinese
-
Abstract:
Glaucoma is a group of optic neuropathies characterized by the progressive loss of retinal ganglion cells and their axons, and has become a leading cause of irreversible blindness worldwide.However, the pathophysiological mechanisms of glaucoma remain poorly understood.Consequently, suitable animal models of glaucoma are crucial for elucidating the disease's pathogenesis and improving therapeutic strategies.In recent years, rodents have increasingly become the preferred choice for glaucoma modeling due to their numerous advantages.With the exception of transgenic mice, which can spontaneously induce glaucoma, experimental glaucoma models are mainly divided into intraocular pressure-dependent and non-intraocular pressure-dependent models.The intraocular pressure-dependent glaucoma model induces intraocular pressure elevation by obstructing aqueous humor outflow in various ways.The non-intraocular pressure-dependent glaucoma model attempts to study the pathogenesis associated with normal intraocular pressure glaucoma.This article comprehensively reviews the damage mechanisms, operation methods, advantages, and limitations of various rodent models of glaucoma.
