Advances in subretinal hyperreflective material in neovascular age-related macular degeneration
10.3760/cma.j.cn115989-20211228-00717
- VernacularTitle:新生血管性年龄相关性黄斑变性中视网膜下高反射物质的研究进展
- Author:
Congbi LIANG
1
;
Changzheng CHEN
Author Information
1. 武汉大学人民医院眼科中心，武汉 430060
- Keywords:
Subretinal hyperreflective material;
Neovascular age-related macular degeneration;
Anti-vascular endothelial growth factor therapy;
Prognosis of visual a
- From:
Chinese Journal of Experimental Ophthalmology
2024;42(5):487-490
- CountryChina
- Language:Chinese
-
Abstract:
Subretinal hyperreflective material (SHRM) is a morphologic feature seen on optical coherence tomography as hyperreflective material outside the retina and within the retinal pigment epithelium.SHRM is common in untreated neovascular age-related macular degeneration (nAMD) and often persists after anti-vascular endothelial growth factor therapy.It is also seen in central serous chorioretinopathy, uveitis, myopic choroidal neovascularization, myopic macular degeneration, Best disease, retinal malnutrition, Erdheim-Chester disease and so on.SHRM is closely associated with loss of the ellipsoid zone, scarring, disruption of outer limiting membrane, macular atrophy and outer retinal tubulations, and is significantly associated with visual impairment.Some SHRM was regression after anti-vascular endothelial growth factor therapy.The prognosis and responses to treatment of SHRM may vary depending on its components and characteristics.Identifying the morphologic characteristics and functional consequences of SHRM in nAMD may deepen the clinical understanding of SHRM.
