Application of resting-state brain mirror homotopic connectivity in patients with concomitant exotropia
10.13389/j.cnki.rao.2024.0166
- VernacularTitle:静息态脑镜像同伦连接在共同性外斜视患者中的应用
- Author:
Juan CHEN
1
;
Jinghua CHENG
;
Han JIN
;
Xin HUANG
Author Information
1. 330006 江西省南昌市,江西省人民医院(南昌医学院第一附属医院)眼科
- Keywords:
concomitant exotropia;
magnetic resonance imaging;
cerebellum;
mirror homotopic connectivity
- From:
Recent Advances in Ophthalmology
2024;44(11):878-882
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the cerebellar hemisphere homotopic functional connectivity in patients with concomitant exotropia(CE)based on voxel-mirrored homotopic connectivity(VMHC),aiming to provide a reference basis for the neuropathogenesis of CE.Methods A total of 36 CE patients who visited the Ophthalmology Department of Jian-gxi Provincial People's Hospital from October 2021 to October 2022 were included as the study group(CE group),while healthy volunteers who were recruited from society and matched in age and gender with the CE group were included as the control group(HC group).Subjects in both groups underwent 3.0T functional magnetic resonance imaging scans,and the magnetic resonance data were processed using DPABI_V4.0 software and SPM8 to compare the differences in VMHC values of various brain regions of subjects in the two groups.Results Compared with the HC group,the VMHC values in the cerebellar regions 6,8 and 9 on both sides and vermis cerebelli region 2 of subjects in the CE group were significantly re-duced(all P＜0.05).The difference pattern of VMHC values in cerebellar regions showed that compared with the HC group,the VMHC values in cerebellar regions 6,8,9 and vermis cerebelli region 2 of subjects in the CE group were signifi-cantly different,especially the VMHC value in cerebellar region 9.Conclusion Functional changes in the cerebellar hemisphere,especially in cerebellar hemisphere region 9,play an important role in the pathogenesis of CE,which may be closely related to eye position voxel control and fusion.
