Progress in the pathogenesis of Graves'ophthalmopathy complicated by dry eyes

VernacularTitle:Graves眼病并发干眼的发病机制研究进展
Author: Jin HUANG ¹ ; Zihong CHEN ; Yina LI ; Ding CHEN
Author Information

1. 325000 浙江省温州市,温州医科大学眼视光学院(生物医学工程学院);325000 浙江省温州市,温州医科大学附属眼视光医院
Keywords: Graves'ophthalmopathy; dry eye; meibomian gland dysfunction; autoimmunity; inflammation; intesti-nal flora imbalance
From: Recent Advances in Ophthalmology 2024;44(9):739-743,748
CountryChina
Language:Chinese
Abstract: Graves'ophthalmopathy(GO),also known as thyroid-associated ophthalmopathy,is an organ-specific au-toimmune disease that ranks first in the incidence of adult orbital diseases.GO has complex clinical manifestations,and dry eyes are a common cause of eye discomfort in patients with this disease.The pathogenesis of concurrent dry eyes is still unclear.It is currently believed that ocular surface damage in patients with GO is a direct factor leading to the occurrence and development of dry eyes.In addition,immunity and inflammation,and intestinal flora imbalance also play a role.Mul-tiple factors interact to form a vicious cycle,which further aggravates dry eyes.This article reviews the research results re-lated to the pathogenesis of GO complicated by dry eyes,aiming to provide ideas for clinical treatment and further research in the field.