Research progress on the role of complement dysregulation in the pathogenesis of Sj?gren's syn-drome

VernacularTitle:补体系统异常在干燥综合征发病机制中的作用研究进展
Author: Mengmeng WANG ¹ ; Haijun MA
Author Information

1. 新乡医学院第一附属医院风湿免疫科,河南卫辉 453100
Keywords: Sj?gren's syndrome; pathogenesis; complement system
From: Journal of Xinxiang Medical College 2024;41(9):890-894
CountryChina
Language:Chinese
Abstract: Sj?gren's syndrome(SjS)is a chronic systemic inflammatory autoimmune disease.Complement dysregulation plays an important role in the pathogenesis of SjS,and hypocomplementemia is closely related to the poor prognosis of SjS patients.However,the exact pathogenesis of complement dysregulation has not been fully elucidated.Based on the activation and regulation of the complement system,this review focuses on the current progress on the complement system in the pathogenesis of SjS,which will provide fundamental support for early diagnosis,disease activity monitoring,therapeutic intervention and prognosis assessment of SjS.