Regulation of cyclicGMP-AMP synthase function by protein post-translational modifications

VernacularTitle:蛋白质翻译后修饰对环磷酸鸟苷-腺苷酸合成酶功能的调控
Author: Mengyang SHEN ¹ ; Chen LU ; Yi WANG ; Jinyong PEI ; Jie WANG ; Bo YANG
Author Information

1. 新乡医学院医学技术学院,河南新乡 453003
Keywords: protein post-translational modifications; cyclic GMP-AMP synthase; signal transduction; innate immunity
From: Journal of Xinxiang Medical College 2024;41(8):701-705
CountryChina
Language:Chinese
Abstract: The cyclic GMP-AMP synthase(cGAS)-stimulator of interferon genes signaling pathway plays a central role in cells'ability to sense the presence of abnormal double-stranded DNA within the cytoplasm.Modulation of the function of the cytoplasmic DNA recognition receptor cGAS allows regulation of this signaling pathway.In recent years,research has identified protein post-translational modifications(PTMs),including phosphorylation,acetylation,ubiquitination,methylation,and SUMOylation,as having significant roles in regulating innate immune signaling pathways.This paper reviews how PTMs influence the function of cGAS and its downstream signaling pathways through various mechanisms.