Research progress on role of ubiquitin-specific proteases in gastric cancer
10.7683/xxyxyxb.2024.05.018
- VernacularTitle:泛素特异性蛋白酶在胃癌中的作用研究进展
- Author:
Yong PENG
1
;
Zhiyuan QIU
Author Information
1. 江苏大学附属人民医院肿瘤科,江苏 镇江 212000
- Keywords:
gastric cancer;
ubiquitin-specific protease;
therapeutic target
- From:
Journal of Xinxiang Medical College
2024;41(5):497-500
- CountryChina
- Language:Chinese
-
Abstract:
Ubiquitin-specific proteases(USPs)are one of the many subfamilies of the deubiquitinating enzyme family,with a variety of functional structural domains and biological functions,which can regulate ubiquitination through the dissocia-tion of ubiquitin from protein substrates,thereby regulating apoptosis,proliferation,metastasis,as well as gene transcription,mesenchymal transition,and immune responses.Ubiquitin is a small protein that marks proteins for degradation and is present in most eukaryotic cells,which hydrolyses proteins through a complex chain reaction of ubiquitination.There are different sites of ubiquitination complex chain reactions,and USPs can act on them and affect ubiquitination in organisms,playing different roles in protein degradation.USPs are expressed in a variety of tumors and participate in tumorigenesis and development through a series of mechanisms,which can be used as cancer therapeutic targets.This article reviews the progress of research on the role of USPs in gastric cancer,in order to provide information for the development of new drugs targeting USPs for the treatment of gastric cancer.
