Effects of dapagliflozin on left ventricular diastolic function in elderly patients with HFpEF during a-cute decompensation
10.3969/j.issn.1008-0074.2024.05.13
- VernacularTitle:达格列净对老年HFpEF急性失代偿期左室舒张功能的影响研究
- Author:
Jin XU
1
;
Song LUO
;
Zhen-Zhen TENG
Author Information
1. 福建省老年医院老年医学科,福建 福州 350001
- Keywords:
Heart failure;
Dapagliflozin;
Aged
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2024;33(5):575-580
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the effects of dapagliflozin on left ventricular diastolic function in elderly patients with heart failure with preserved ejection fraction(HFpEF)during acute decompensation.Methods:A total of 160 elderly patients with HFpEF during acute decompensation treated in Department of Geriatrics,Fujian Provincial Geriatric Hospital were retrospectively enrolled between January 2021 and January 2024.According to different therapeutic regimens,they were divided into routine treatment group(n=80,routine anti-heart failure drug thera-py)and combined dapagliflozin treatment group(n=80,dapagliflozin on basis of routine anti-heart failure drug therapy).All patients were treated for 3 months.The clinical curative effect,changes of left ventricular diastolic function indexes[early diastolic mitral annular peak velocity(e'),ratio of left ventricular early diastolic filling peak velocity(E)to e'(E/e'),tricuspid regurgitation velocity(TRV),left atrial diameter(LAD)],inflammatory factors[serum amyloid A(SAA),high sensitive C-reactive protein(hsCRP),interleukin-6(IL-6)],myocardial enzymes[lactate dehydrogenase(LDH),creatine kinase(CK),creatine kinase isoenzyme(CK-MB),α-hydroxybutyrate dehy-drogenase(α-HBDH)]and N-terminal pro brain natriuretic peptide(NT-proBNP),and the occurrence of adverse re-actions were compared between the two groups.Results:Compared with routine treatment group,total effective rate was significantly higher in combined dapagliflozin treatment group(85.00％vs.95.00％,P=0.035).After treatment,E/e',TRV,LAD,levels of SAA,hsCRP,IL-6,LDH,CK,CK-MB,α-HBDH and NT-proBNP in combined dapaglifloz-in treatment group were significantly lower than those in routine treatment group(P＜0.01 all).There was no significant difference in the incidence rate of adverse reactions between the two groups(P=0.718).Conclusion:Dapagliflozin can significantly improve left ventricular diastolic function and effectively alleviate the progression of heart failure in elderly pa-tients with HFpEF during acute decompensation,which has certain clinical significance.
