Exosome regulation of ferroptosis:a new idea for the treatment of cardiovascular diseases
10.3969/j.issn.1008-0074.2024.04.28
- VernacularTitle:外泌体调控铁死亡:心血管疾病治疗的新思路
- Author:
Shao-Lin LI
1
;
Shu-Ying ZHANG
Author Information
1. 大连大学附属中山医院心血管内科,辽宁大连 116001
- Keywords:
Cardiovascular diseases;
Ferroptosis;
Exosome
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2024;33(4):512-515
- CountryChina
- Language:Chinese
-
Abstract:
Ferroptosis is a new pattern of cell death characterized by increased lipid reactive oxygen species and accu-mulation of intracellular ferrous ions.Many studies have verified the complex relationship between ferroptosis and cardiovascular diseases,and intervention of ferroptosis has become a new therapeutic idea for cardiovascular disea-ses.Based on the inherent characteristics of cardiovascular diseases and cell injury,the present article discusses the theoretical basis of ferroptosis in the treatment of cardiovascular diseases.We review the association between ferrop-tosis and cardiovascular diseases in terms of epigenetics and the role of stem cell exosomes.Exosomes can deliver dif-ferent molecules to regulate the death pathways of cardiomyocytes and vascular endothelial cells.Intervention of ferroptosis in target cells with exosomes is a new potential therapeutic target and research direction for the treatment of cardiovascular diseases in the future.
