Predictive value of neutrophil-to-HDL-C ratio and monocyte-to-HDL-C ratio for degree of coronary ste-nosis
10.3969/j.issn.1008-0074.2024.04.19
- VernacularTitle:中性粒细胞与HDL-C比值和单核细胞与HDL-C比值对冠状动脉狭窄程度的预测价值
- Author:
Jia-Li JIN
1
;
Jing MA
;
Tian LIANG
;
Ling WANG
Author Information
1. 哈尔滨医科大学附属第一医院心内科,黑龙江哈尔滨 150001
- Keywords:
Coronary stenosis;
Neutrophils;
Monocytes;
Lipoproteins,HDL
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2024;33(4):471-475
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the predictive value of neutrophil-to-high density lipoprotein cholesterol ratio(NHR)and monocyte-to-high density lipoprotein cholesterol ratio(MHR)for degree of coronary stenosis.Meth-ods:A retrospective analysis was performed on 273 patients who underwent coronary angiography(CAG)and ad-mitted in the Department of Cardiology of our hospital from October 2021 to April 2022.According to CAG results,they were divided into normal coronary group(n=89),mild-moderate disease group(n=97,0＜Gensini score≤40 points)and severe disease group(n=87,Gensini score＞40 points).NHR and MHR were compared among three groups.ROC curve was used to analyze predictive value of NHR and MHR for degree of coronary stenosis.Results:Compared with normal coronary group,there were significant rise in MHR[0.35(0.27,0.43)vs.0.49(0.34,0.64)vs.0.47(0.35,0.63)]and NHR[3.63(3.01,4.76)vs.4.91(3.77,6.52)vs.5.86(4.65,7.98)]in mild-moderate disease group and severe disease group(P＜0.001 all),and NHR in severe disease group was signif-icantly higher than that of mild-moderate disease group(P=0.022).ROC curve indicated that area under the curve(AUC)of NHR predicting mild-moderate disease and severe disease was 0.723(95％CI:0.651～0.795)and 0.820(95％CI:0.757～0.882)respectively;and AUC of MHR predicting mild-moderate disease and severe disease was 0.689(95％CI:0.612～0.766)and 0.706(95％CI:.0.628～0.882)respectively.Conclusion:NHR and MHR have strong predictive value for the severity of coronary artery stenosis,and the predictive value increases as the stenotic degree aggravates.
