Effect of bisoprolol combined with ticagrelor on levels of Galectin-3 and CEACAM1 in patients with acute myocardial infarction after PCI
10.3969/j.issn.1008-0074.2024.04.09
- VernacularTitle:比索洛尔联合替格瑞洛对急性心肌梗死患者PCI术后Galectin-3、CEACAM 1水平的影响
- Author:
Tao JIANG
1
;
Yan-Na XU
;
Ya-Yun ZHANG
Author Information
1. 保定市第二中心医院心内一科,河北保定 072750
- Keywords:
Myocardial infarction;
Galectin 3;
Bisoprolol;
Ticagrelor
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2024;33(4):420-425
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of bisoprolol combined with ticagrelor on levels of Galectin-3,carci-noembryonic antigen-related cell adhesion molecule 1(CEACAM1)in patients with acute myocardial infarction(AMI)after percutaneous coronary intervention(PCI).Methods:A total of 140 AMI patients underwent PCI in our hospital from May 2019 to June 2021 were selected.According to coin-toss method,they were divided into control group(n=70)and combined group(n=70).Both groups received aspirin,control group received ticagrelor on this basis,while combined group received ticagrelor combined bisoprolol on the basis.Both groups were treated for two weeks.Levels of Galectin-3,CEACAM1,serum N terminal pro B-type natriuretic peptide(NT-proB-NP),tumor necrosis factor-α(TNF-α),nitric oxide(NO),endothelin-1(ET-1)and malondialdehyde(MDA)before and after treatment,therapeutic effect and incidence of adverse reactions were compared between two groups.Results:Compared with control group after treatment,combined group showed significant reductions in levels of Galectin-3[(34.67±2.34)ng/L vs.(28.54±1.92)ng/L],CEACAM1[(229.64±17.36)pg/mlvs.(175.54±11.97)pg/ml],NT-proBNP[(196.49±20.83)ng/L vs.(103.46±16.35)ng/L],TNF-α[(5.68±0.72)mg/L vs.(3.23±0.57)mg/L],ET-1[(59.47±4.74)ng/L vs.(45.29±3.84)ng/L]and MDA[(8.42±0.96)μmol/L vs.(5.03±0.46)μmol/L],and significant increase in NO level[(72.34±5.69)μmol/L vs.(92.16±6.61)μmol/L](P＜0.001 all).Total effective rate(94.29％vs.75.71％)of combined group was signif-icantly higher than that of control group(P=0.002),while incidence rate of adverse reactions(1.43％vs.14.29％)was significantly lower than that of control group(P=0.005).Conclusion:Ticagrelor combined with bi-soprolol can significantly reduce levels of Galectin-3 and CEACAM1,improve the therapeutic effective rate with good safety in AMI patients,which is worthy of promotion and application.
