Predictive value of neutrophil count and neutrophil-to-lymphocyte ratio for coronary artery disease degree in diabetic patients
10.3969/j.issn.1008-0074.2024.04.08
- VernacularTitle:中性粒细胞计数和中性粒细胞与淋巴细胞比值对糖尿病患者冠状动脉病变程度的预测价值
- Author:
Di LIU
1
;
Yu-Hui DONG
Author Information
1. 哈尔滨医科大学附属第一医院内分泌科,黑龙江哈尔滨 150001
- Keywords:
Diabetes mellitus;
Coronary artery disease;
Neutrophils
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2024;33(4):416-419
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the predictive value of neutrophil count and neutrophil-to-lymphocyte ratio(NLR)for severity of coronary artery lesions in diabetic patients.Methods:Clinical data of 287 diabetic patients who admitted to our Department of Cardiology and received coronary angiography(CAG)from September 2021 to April 2022 were retrospec-tively analyzed.According to CAG results,they were divided into normal coronary group(n=94),mild-moderate disease group(0＜Gensini score≤40 points,n=102)and severe disease group(Gensini score＞40 points,n=91).Neutrophil count and NLR were compared among three groups.ROC curve was used to analyze the predictive value of neutrophil count and NLR for severity of coronary artery disease in diabetic patients.Results:Compared with normal coronary group,there were significant rise in neutrophil count[4.17(3.31,4.88)×109/Lvs.4.96(4.28,6.07)×i09/Lvs.5.57(4.62,7.03)×109/L]and NLR[2.25(1.74,2.72)vs.3.18(2.48,3.66)vs.3.49(3.03,4.32)]in mild-moderate dis-ease group and severe disease group(P＜0.001 all).Binary Logistic regression analysis indicated that neutrophil count(OR=1.566,P＜0.001)and NLR(OR=2.152,P＜0.001)were independent risk factors for coronary disease in diabetic patients.ROC indicated that neutrophil count[area under the curve(AUC)=0.750]and NLR(AUC=0.775)possessed good predictive value for severity of coronary artery disease in diabetic patients.Conclusion:Neutrophil count and NLR are closely associated with coronary artery disease degree in diabetic patients,which possess good predictive value.
