The change and clinical significance of serum miR-34a expression in patients with acute ST-segment elevation myocardial infarction
10.3969/j.issn.1008-0074.2024.04.07
- VernacularTitle:急性ST段抬高型心肌梗死患者血清miR-34a表达变化及临床意义
- Author:
Yong LI
1
;
Hai-Gang HE
;
He-Ping QIAN
Author Information
1. 江苏省南通市海门区人民医院心血管内科 江苏南通 226100
- Keywords:
Myocardial infarction;
MicroRNAs;
Creatine kinase,MB form;
Superoxide dismutase
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2024;33(4):411-415
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression and clinical significance of serum microRNA-34a(miR-34a)in patients with acute ST-segment elevation myocardial infarction(STEMI).Methods:A total of 83 STEMI patients diagnosed and treated in our hospital from May 2018 to May 2022 were selected as STEMI group,and 83 healthy subjects undergoing physical examination simultaneously were selected for a control study(healthy group).The gen-eral data and serum levels of miR-34a expression,creatine kinase isoenzyme MB(CK-MB)and superoxide dis-mutase(SOD)were compared between two groups;Pearson method was used to analyze the correlation among ser-um levels of CK-MB,SOD and miR-34a expression in STEMI patients;Logistic regression was used to analyze the influencing factors of STEMI.Results:Compared with healthy group,there were significant rise in levels of LDL-C[(2.18±0.73)mmol/L vs.(2.60±0.87)mmol/L],TC[(3.82±0.75)mmol/L vs.(4.10±0.82)mmol/L],TG[(1.38±0.35)mmol/L vs.(1.75±0.44)mmol/L],miR-34a expression[(1.04±0.35)vs.(2.03±0.68)]andCK-MB[(18.12±8.27)U/L vs.(75.44±36.08)U/L](P＜0.05 or＜0.01),and signifi-cant reduction in serum SOD level[(146.23±50.81)μU/L vs.(75.62±26.96)μU/L]in STEMI group(P＜0.001).Pearson correlation analysis indicated that serum miR-34a expression level was significant positively corre-lated with CK-MB level(r=0.591,P＜0.001),and significant inversely correlated with SOD level(r=-0.588,P＜0.001)in STEMI patients.Logistic regression analysis indicated that LDL-C,miR-34a and TG were inde-pendent risk factors for STEMI(OR=2.768～66.754,P＜0.05 or＜0.01),while SOD was its independent protec-tive factor(OR=0.955,P＜0.001).Conclusion:The expression level of serum miR-34a is higher in STEMI pa-tients,which is significantly related to myocardial injury and oxidative stress indicators.MiR-34a may be a poten-tial target for the diagnosis and treatment of STEMI.
